Hairan syndrome as a rare cause of primary amenorrhea, hyperandro- genism, insulin resistance and acanthosis nigricans in adolescents: A case report and review of literature

HAIRAN syndrome is a very rare syndrome which manifests with hyperandrogenism, insulin resistance and acanthosis nigricans. The syndrome usually presents with symptoms during adolescent period of life time. These pattients can easily be misdiagnosed as polycystic ovary syndrome both of which has resembling signs and symptoms. Clinical examination, gynecological evaluation and laboratory investigations are mandatory to differentiate these two syndromes. Metabolic consequences of the syndrome increases the risk of cardiovasculary disease in the future life of these adolescent patients. Counseling about the importance of weight reduction and control of insulin resistance by utilization of medical treatment for menstrual irregularies and hirsutism are key steps during management of this syndrome.